KOTAR SINDROMI (SINDROME DE COTARD): ETIO-PATOGENETIK MEXANIZMLARI, KLINIK STRUKTURASI, ZAMONAVIY DAVOLASH REJIMLARI VA PROFILAKTIKA ASOSLARI

Authors

  • Xamidjonova Ziyoda Dilshod qizi University of business and Science Davolash ishi yo'nalishi 25-14 guruh talabasi Author
  • Turgunboyeva Safura Ikrom qizi University of Business and Science Davolash ishi yo‘nalishi 25-14 guruh talabasi Author
  • Solijonov Muhammadqodir Bahodir ogʻli University of Business and Science Davolash ishi yo‘nalishi 25-14 guruh talabasi Author
  • Olimjonov Yaxyobek Yoqubjon oʻgʻli University of Business and Science Davolash ishi yo‘nalishi 25-14 guruh talabasi Author
  • Xusanova Nozima Xusanboy qizi University of Business and Science Davolash ishi yo‘nalishi 25-14 guruh talabasi Author
  • To'lqinova Xurshida Rahimjon qizi University of Business and Science Davolash ishi yo‘nalishi 25-14 guruh talabasi Author

Keywords:

Kotar sindromi, nihilistik alahsirash, erta prefrontal po‘stloq, neyromediatorlar, og‘ir depressiya, elektrokonvulsiv terapiya, psixofarmakoterapiya, profilaktika.

Abstract

Ushbu maqolada psixiatriya va klinik nevrologiya amaliyotida kam uchraydigan, og‘ir kechuvchi psixopatologik holat — Kotar sindromining (nihilistik alahsirash) etiopatogenezi, klinik kechishi va uning miya neyroanatomiyasi bilan bog‘liqligi tahlil qilingan. Kasallik asosida yotuvchi endogen psixozlar, organik miya zararlanishlari hamda neyromediatorlar disbalansining bemorlarda o‘z organlari yo‘qligi yoki o‘zining o‘lganligi haqidagi fojiali nihilistik g‘oyalarni yuzaga keltirish mexanizmlari yoritilgan. Tadqiqot davomida patologiyaning differensial tashxislash me’zonlari, zamonaviy kombinatsiyalashgan farmakoterapiya (antidepressantlar, antipsixotiklar), elektrokonvulsiv terapiya (EKT) hamda asoratlarning oldini olishga qaratilgan profilaktik chora-tadbirlar klinik jihatdan asoslab berilgan.

References

1. Berrios, G. E., & Luque, R. (1995). Cotard's delusion or syndrome? A conceptual history. Comprehensive Psychiatry, 36(3), 218-223.

2. Debruyne, H., Portzky, M., Van den Eynde, F., et al. (2011). Cotard's syndrome: a review. Current Psychiatry Reports, 13(3), 228-235.

3. Sati Das, S., & Shibu, M. (2020). Electroconvulsive therapy in drug-resistant Cotard's syndrome: a clinical analysis. The Journal of ECT, 36(2), 114-119.

4. Xalilov, A. R., & tursunov, Sh. S. (2023). Ogʻir depressiv buzilishlar fonida kuzatiladigan Kotar sindromining klinik-psixopatologik xususiyatlari va davolash taktikasi. Oʻzbekiston Psixiatriya Jurnali, 2(14), 50-56.

5. Nazarova, G. K. (2024). Bosh miya organik kasalliklarida nihilistik alahsirash fenomenologiyasi va neyrovizualizatsiya me’zonlari. Tibbiyotda Yangi Kun, 1(49), 132-138.

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Published

2026-06-15

Issue

Vol. 2 No. 6 (2026): INTERNATIONAL CONFERENCE OF SCIENCE & TECHNOLOGY

Section

Articles