ENDOMETRIAL MICROBIOTA AND ITS IMPACT ON IMPLANTATION SUCCESS

Authors

  • Barnoxonim Yuldasheva Alfraganus University, Faculty of Medicine 4th-year Medical Student, Clinical Internship Author

Keywords:

Endometrial microbiota, implantation, embryo transfer, endometrial receptivity, assisted reproductive technology, reproductive outcomes, microbial diversity

Abstract

The endometrial microbiota has emerged as a key factor influencing female reproductive health and implantation outcomes. This article reviews current evidence on the composition and diversity of the endometrial microbiome and its role in modulating endometrial receptivity, immune response, and embryo implantation. The potential clinical implications for assisted reproductive technologies (ART) and strategies to optimize implantation success through microbiota modulation are also discussed.

References

1. Moreno, I., et al. (2016). The endometrial microbiota and its impact on implantation success: Insights from next-generation sequencing. Fertility and Sterility, 106(3), 657–665.

2. Franasiak, J. M., & Scott, R. T. (2015). Endometrial microbiome and its role in reproductive outcomes. Fertility and Sterility, 104(5), 1242–1249.

3. Koedooder, R., et al. (2019). The endometrial microbiome in IVF patients: Predictive value for implantation success. Human Reproduction, 34(6), 1042–1054.

4. Ata, B., et al. (2019). Endometrial microbiome: Clinical implications for assisted reproduction. Current Opinion in Obstetrics and Gynecology, 31(3), 147–153.

5. Haahr, T., et al. (2019). Abnormal vaginal microbiota and poor reproductive outcomes in IVF patients. Human Reproduction, 34(9), 1681–1692.

6. Koedooder, R., et al. (2018). Lactobacillus-dominated endometrium and IVF success: A multicenter study. Reproductive BioMedicine Online, 36(5), 598–608.

7. Moreno, I., & Simon, C. (2018). Endometrial microbiota: New perspectives for reproductive medicine. Fertility and Sterility, 110(3), 347–353.

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Published

2025-09-29