SYNTHESIS OF 2-METHOXYCARBONYLAMINOQUINAZALIN-4-ONE
Keywords:
Quinazolin-4-one, biological activity, nitrating compound, recrystallization, electrophilic coupling, system.Abstract
Based on the research on the synthesis of quinazolin-4-ones and their derivatives, a number of research works have been carried out on finding new nootropic and psychotropic drugs and studying their biological activity. Synthetic quinazoline derivatives used in medicine have high psychotropic (methaqualone), diuretic (kinetazone), cardiovascular (prazosin) and antiviral (quinazoline analogs of efavirenz) activity [1 1079-1084 pp.]. In addition, 2-methoxycarbonyl-aminoquinazolin-4-one, synthesized by the authors on the basis of quinazolin-4-one, is a highly effective tool in the complex fight against cotton gommosis and root rot diseases.
References
1. Aliyalu Rajasekaran, Velayuthem Rajamanickam, Sabarimuthu darlinquine. Synthesis, Anti-Immflatory and Analgesic Evaluationof Thioxoquinazoline Derivates. The Pharmaceutical Society of Japan, 2011, -pp. 1079-1084.
2. V.N.Britsun., A.N.Esipenko., V.I.Staninets et al. Structure of halocyclization products of 2-allylsulfanyl-3-amino-3,4-dihydroquinazolin-4-one // Journal of Heterocyclic Chemistry, 2005, Volume 41, №7. –pp. 948-949.
