MOLECULAR ROLE OF MATRIX METALLOPROTEINASES AND THEIR INHIBITORS IN INFLAMMATORY KIDNEY DISEASES
Keywords:
matrix metalloproteinases, tissue inhibitors of metalloproteinases, inflammatory kidney diseases, extracellular matrix, renal tissue remodeling, fibrosis, molecular mechanismsAbstract
The article presents an expanded scientific rationale for the role of matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) in the development of inflammatory kidney diseases. Particular attention is paid to molecular mechanisms, pathophysiological chanGES, and modern concepts of renal tissue remodeling, in accordance with the requirements of European scientific journals.
References
1. Крутова А.С. эт ал. Паcифиc Медиcал Жоурнал, 2020.
2. Вялкова А.А. эт ал. Непҳрологй, 2019.
3. Базарова Н. эт ал. БИО Wеб оф Cонференcес, 2024.
4. Мусиаł К. эт ал. Педиатриc НепҳрологVyalkova A.A., Zorin I.V., Chesnokova S.A., Plotnikova S.V. Chronic kidney disease in children. Nephrology. 2019;23(5):29 https://doi.org/10.24884/1561-6274-2019-23-5-29. (in Russ).
5. Vyalkova A.A., Zorin I.V., Karymova G.K., Chesnokova S.A. Polymorphism of genes of immune-inflammatory response, thrombophilia and arterial hypertension in kidney diseases in children (literature review). Nephrology2022;26(3):40-51. https://doi.org/10.36485/1561-6274-2022-26-3-40-51. (in Russ).
6. Krutova A.S., Luchaninova V.N., Semeshina O.V., Ni A., Bykova O.G. The role of matrix metalloproteinases and their inhibitors in physiopathological processes in children with kidney diseases. Pacific Medical Journal,2020;(1):11-https://doi.org/10.34215/1609-1175-2020-1-11-15. (in Russ).
7. Bazarova N. et al. Determination of the relationship between the polymorphic genes of metaloproteinases MMP9 (A-8202G) RS11697325 and the level of cystatin c in children with chronic nephritic syndrome //BIO Web of Conferences. – EDP Sciences, 2024. – Т. 121. – С. 03011.
8. https://doi.org/10.1051/bioconf/202412103011 (in English.).
9. Bazarova N.S., Ziyadullaev Sh.Kh. Comprehensive assessment of various forms of chronic chronic nephritic syndrome in children. “Web of scientist: International scientific research journal” Indonesia. No. 3. Vol. 5 pp. 12-17 May. 2022.https://doi.org/10.17605/OSF.IO/P2BZXй,2015
