THE ROLE OF BCL-2 IN TUMORIGENESIS
Keywords:
BCL-2, BCL-XL, genetic, apoptosis, lymphomaAbstract
Apoptosis is a genetically regulated process of programmed cell death in eukaryotes, essential for normal development and the maintenance of homeostasis. As a crucial physiological mechanism, apoptosis selectively eliminates cells and regulates cell death. It occurs not only in response to damage or external stress but also during normal cell development and morphogenesis.
References
1. Novitsky V.V., Urazova O.I. “Pathological Physiology” – Cellular Damage, pp. 132–191.
2. Imyanitov E.N., Khanson K.P. Molecular Oncology: Clinical Aspects, St. Petersburg: SPMAPO, 2007 – 211 p.
3. Huang C., Freter C.E. Lipid metabolism, apoptosis, and cancer therapy. Int J Mol Sci. 2015;16(1):924–49.
4. Kamal S., Riaz U., Qadri I. Applications of microbial lipases in cancer treatments: a novel therapeutic approach. Biomed Res Int. 2016;2016:4370305.
5. Bertheau P., Plassa F., Espié M., et al. (2002). Effect of mutated TP53 on response of advanced breast cancers to high-dose chemotherapy. Lancet, 360: 852–855.
6.Bertheau P., Turpin E., Rickman D.S., et al. (2007). Exquisite sensitivity of TP53 mutant and basal breast cancers to a dose-dense epirubicin-cyclophosphamide regimen. PLoS Med., 4: e90
