CAUSES AND CONSEQUENCES OF POLYCYSTIC OVARY SYNDROME IN ADOLESCENCE: A COMPREHENSIVE REVIEW
Keywords:
To review current evidence on the etiological factors and the short- and long-term consequences of PCOS in adolescents; to propose a conceptual model of causation and impact; and to identify gaps for future research.Abstract
Polycystic Ovary Syndrome (PCOS) is a common endocrine-metabolic disorder affecting women of reproductive age, often beginning in adolescence. Its causes are multifactorial; its consequences involve reproductive, metabolic, and psychological outcomes.
References
1. Zhu T, Goodarzi MO. Causes and Consequences of Polycystic Ovary Syndrome: Insights From Mendelian Randomization. Journal of Clinical Endocrinology & Metabolism. 2022.
2. Ali AT, Al ani O, Al ani F, Guidozzi F. Polycystic ovary syndrome and metabolic disorders: A review of the literature. African Journal of Reproductive Health. 2022; 26(8): 89 99.
3. MDPI. Polycystic Ovary Syndrome: Pathophysiology and Controversies in Diagnosis.
4. Physiopathology of Polycystic Ovary Syndrome in Endocrinology, Metabolism and Inflammation. Journal of Ovarian Research. 2025; article.
5. Polycystic Ovary Syndrome: Etiology, Current Management, and Future Therapeutics. PMC.
6. Polycystic Ovarian Syndrome in Adolescents – Journal article.
7. An International Consortium Update: Pathophysiology, Diagnosis, and Treatment of Polycystic Ovarian Syndrome in Adolescence. Karger.
8. Polycystic Ovary Syndrome: Pathophysiology, Presentation, and Treatment With Emphasis on Adolescent Girls.
9. Review Article On Polycystic Ovary Syndrome. Indian Journal of Psychological Science or similar.
10. PCOS Challenges and Possible Solutions. MDPI.
11. Additional epidemiological studies linking PCOS with adolescent metabolic syndrome and cardiovascular risk.
12. Others: environmental pollutant studies (EDCs), gut dysbiosis literature.
13. Genetic studies aside from Zhu & Goodarzi (e.g. GWAS).
14. Inflammation & oxidative stress studies.
15. Psychological outcome studies.
