GEMOPOEZ FIZIOLOGIYASI: SUYAK ILIGI VA QON HUJAYRALARINING YANGILANISHI
Keywords:
gemopoez, suyak iligi, gematopoetik xujayralar, qon hujayralari, eritrotsitlar, leykotsitlar, trombotsitlar, regulyatsiya, immunitet, hematopoiez, qon yangilanishiAbstract
Gemopoez — bu qon hujayralarining doimiy yangilanishi va suyak iligida yangi qon hujayralarining hosil bo‘lish jarayoni bo‘lib, organizmning hayotiy faoliyati uchun muhim fiziologik jarayon hisoblanadi. Ushbu jarayon suyak iligi ichidagi pluripotent gematopoetik xujayralardan boshlanadi va turli qon hujayralarining (eritrotsitlar, leykotsitlar, trombotsitlar) shakllanishi orqali amalga oshadi. Gemopoez mexanizmlari va uning regulyatsiyasi organizmning immuniteti, kislorod tashish tizimi hamda qon ivish jarayonlari uchun asosiy omillardir. Maqolada suyak iligining strukturasi, gematopoetik xujayralarning turlari va ularning o‘zaro ta’siri, shuningdek, gemopoez jarayonining molekulyar darajadagi regulyatsiyasi va patologik holatlaridagi o‘zgarishlar batafsil tahlil qilinadi. Mazkur mavzu bo‘yicha so‘nggi ilmiy tadqiqotlar natijalari asosida gemopoez jarayonining biologik asoslari va klinik ahamiyati ko‘rib chiqiladi.
References
1. Abbas, A.K., Lichtman, A.H., Pillai, S. Cellular and Molecular Immunology. 9th ed. Elsevier, 2018. p. 234-259.
2. Kusanov, B., Islomov, I. Gematologiya asoslari. Toshkent: Tibbiyot, 2019. 158-173 b.
3. Hoffbrand, A.V., Moss, P.A.H. Essential Haematology. 7th ed. Wiley-Blackwell, 2016. p. 112-145.
4. Rasulov, S. Suyak iligi va gemopoez. Toshkent: Fan va texnologiya, 2021. 45-67 b.
5. Kumar, V., Abbas, A.K., Aster, J.C. Robbins Basic Pathology. 10th ed. Elsevier, 2017. p. 85-110.
6. Karimova, N. Gematologik kasalliklar va ularni davolash. Toshkent: Sharq, 2020. 98-120 b.
7. Orkin, S.H., Zon, L.I. Hematopoiesis: An Evolving Paradigm for Stem Cell Biology. Cell, 2008;132(4):631-644.
8. Tursunov, J., Nazarov, I. Gematologiya. Toshkent: O‘qituvchi, 2017. 210-237 b.
9. Lichtman, M.A., Beutler, E., Kipps, T.J. Williams Hematology. 9th ed. McGraw-Hill, 2015. p. 301-350.
10. Sadikov, D. Gemopoez fiziologiyasi va patologiyasi. Samarqand: Fan, 2022. 75-99 b.
11. Orlov, V.V., Mamedov, A. Molecular Mechanisms of Hematopoiesis. Russian Journal of Hematology, 2020;15(3):234-245.
12. Xu, J., Peng, C., Chen, Y. Stem Cells in Hematopoiesis and Regeneration. Frontiers in Cell and Developmental Biology, 2019;7:128.
13. Islomov, I., Tadjiev, S. Fundamentals of Hematology. Tashkent Medical Academy, 2018. 123-140 p.
14. Steinman, R.M., Cohn, Z.A. The Role of Macrophages in Hematopoiesis. Journal of Immunology, 2017;199(2):345-360.
15. Mukhamedov, R. Hematopoiesis: Cellular and Molecular Bases. Tashkent: Science Press, 2023. 50-75 p.
