CARDIAC HYPERTROPHY: ANATOMICAL FEATURES AND ETIOLOGY

Authors

  • Rahimova Mohinur Azmiddin qizi 3rd-year student, Faculty of Pediatrics Samarkand State Medical University Author
  • Ergasheva Mamura Toshtemirovna Assistant, Department of Internal Diseases Propaedeutics Samarkand, Uzbekistan Author

Keywords:

cardiac hypertrophy, left ventricular hypertrophy, right ventricular hypertrophy, arterial hypertension, valvular stenosis, valvular regurgitation, hypertrophic cardiomyopathy, myocardial growth, interstitial fibrosis, heart failure, arrhythmias, pathophysiology, electrocardiography, echocardiography, magnetic resonance imaging, circulatory impairment, structural heart changes, physical overload

Abstract

Cardiac hypertrophy is a pathological thickening of the heart muscle that causes significant alterations in the structure and function of the heart. This condition commonly arises due to arterial hypertension, valvular stenosis and regurgitation, hypertrophic cardiomyopathy, pulmonary-related heart diseases, and excessive physical workload. The main anatomical and pathophysiological characteristics include an increase in the size and mass of cardiomyocytes, hypertrophy of muscle fibers, and development of interstitial fibrosis. These changes reduce the heart’s pumping efficiency, leading to impaired circulation, heart failure, arrhythmias, and increased risk of mortality. Modern diagnostic methods such as electrocardiography (ECG), echocardiography (ECHO), and magnetic resonance imaging (MRI) allow precise assessment of the degree of hypertrophy and cardiac function. This article provides a comprehensive overview of the anatomical alterations, pathophysiology, primary causes, and diagnostic techniques of cardiac hypertrophy, along with clinical implications and treatment approaches. Early detection and effective management of cardiac hypertrophy are crucial in reducing cardiovascular disease complications.                       

References

1. Braunwald, E. Braunwald's Heart Disease: A Textbook of Cardiovascular Medicine. 11th Edition. Elsevier, 2018.

2. Lilly, L. S. Pathophysiology of Heart Disease: A Collaborative Project of Medical Students and Faculty. 6th Edition. Wolters Kluwer, 2016.

3. Zipes, D. P., Libby, P., Bonow, R. O., Mann, D. L., Tomaselli, G. F. Braunwald's Heart Disease. 12th Edition. Elsevier, 2021.

4. Maron, B. J., Gardin, J. M., Flack, J. M., et al. “Prevalence of Hypertrophic Cardiomyopathy in a General Population of Young Adults.” Circulation, 1995;92(4):785-789.

5. Elliott, P., Anastasakis, A., Borger, M. A., et al. “2014 ESC Guidelines on diagnosis and management of hypertrophic cardiomyopathy.” European Heart Journal, 2014;35(39):2733-2779.

6. Spirito, P., Autore, C., Formisano, F., et al. “Exercise and Hypertrophic Cardiomyopathy: Insights from Genetic and Clinical Studies.” Heart, 2017;103(1):1-6.

7. Cohn, J. N., Ferrari, R., Sharpe, N. “Cardiac remodeling—concepts and clinical implications: a consensus paper from an International Forum on Cardiac Remodeling.” J Am Coll Cardiol, 2000;35(3):569-582.

8. Gerdts, E., Regitz-Zagrosek, V. “Sex differences in cardiometabolic disorders.” Nat Rev Cardiol, 2019;16(1):31-42.

9. Oparil, S., Acelajado, M. C., Bakris, G. L., et al. “Hypertension.” Nature Reviews Disease Primers, 2018;4:18014.

10. Erkinov, A. A., Yakubov, A. Z., Yuldashev, A. K. Kardiologiya. Tashkent: “Meditsina” nashriyoti, 2015. (O‘zbek tibbiy manbasi)

11. Kitzman, D. W., Gardin, J. M., Gottdiener, J. S., et al. “Importance of left ventricular diastolic dysfunction in heart failure with preserved systolic function.” J Am Coll Cardiol, 2002;39(7):955-962.

12. Galderisi, M. “Echocardiography for hypertrophic cardiomyopathy.” Heart Failure Clinics, 2010;6(1):11-22.

13. Rakhimov, M. A., Karimov, B. T., Yuldoshev, T. A. Ichki kasalliklar. Tashkent, 2019. (O‘zbek tilida darslik)

14. Maron, B. J., Ommen, S. R., Semsarian, C., Spirito, P., Olivotto, I., Maron, M. S. “Hypertrophic Cardiomyopathy: Present and Future, With Translation Into Contemporary Cardiovascular Medicine.” J Am Coll Cardiol, 2014;64(1):83-99.

15. Towbin, J. A., McKenna, W. J., Abrams, D. J., et al. “2019 HRS expert consensus statement on evaluation, risk stratification, and management of arrhythmogenic cardiomyopathy.” Heart Rhythm, 2019;16(11):e301-e372.

16. Zipes, D. P., Jalife, J. Cardiac Electrophysiology: From Cell to Bedside. 7th Edition. Elsevier, 2018.

17. Islomov, A. K., Tursunov, B. A. Kardiologiya va terapiya. Tashkent, 2020.

Downloads

Published

2025-09-12