GEN TERAPIYASI ENDOKRINOLOGIYADA: PATOGENEZ, ILMIY TAHLIL VA STATISTIK MA'LUMOTLAR
Keywords:
gen terapiyasi, endokrinologiya, qandli diabet, monogen diabet, metabolik endokrin kasalliklar, beta-hujayralar, DNK tuzatish, klinik tajribalar, CRISPR-Cas9, virus vektorlar.Abstract
Gen terapiyasi – bu kasallikni DNK darajasida davolash usuli bo'lib, u orqali irsiy va surunkali endokrin kasalliklar, xususan 1-tur qandli diabet (autoimmun mexanizm bilan bog'liq), monogen (irsiy) diabetlar (MODY, neonatal diabet kabi bitta gen defekti bilan bog'liq), metabolik endokrin kasalliklar (qalqonsimon bez, adrenal yetishmovchilik va boshqa gormon disbalanslari) uchun barqaror va uzoq muddatli davolash strategiyasini taklif etiladi. Maqolada har bir yo'nalishning patogenezi, gen terapiyasining molekulyar asoslari, klinik tajribalar va statistik ma'lumotlar tahlil qilingan. Tadqiqotlar shuni ko'rsatadiki, gen terapiyasining xavfsizlik va samaradorlik ko'rsatkichlarini oshirish orqali klinik amaliyotda innovatsion davolash protokollarini yaratish mumkin. Global miqyosda qandli diabet bilan kasallanish sonining ortib borayotgani endokrinologiyada gen terapiyasini joriy etishning dolzarbligini ko'rsatadi
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