CHANGES IN BRAIN BIOENERGETICS UNDER HYPOTHERMIC CONDITIONS
Keywords:
Brain bioenergetics, hypothermia, neuronal metabolism, mitochondrial function, atp production, glucose utilization, oxygen consumption, synaptic transmission, neuroprotection, cerebral metabolic rate, enzyme activity, low-temperature brain physiology, therapeutic hypothermia, energy homeostasis, cerebral ischemia.Abstract
This article reviews the effects of hypothermic conditions on brain bioenergetics, focusing on metabolic, cellular, and molecular adaptations. Hypothermia significantly alters neuronal energy metabolism, mitochondrial function, and ATP production, which can impact synaptic transmission and neuroprotection. The study analyzes current research on the mechanisms underlying reduced cerebral metabolic rates during hypothermia, including changes in glucose utilization, oxygen consumption, and enzyme activity. Furthermore, the article discusses potential therapeutic applications of controlled hypothermia in clinical settings, such as neuroprotection after ischemic injury or cardiac arrest. The findings highlight the importance of understanding bioenergetic responses to hypothermia for improving patient outcomes and developing new strategies for brain preservation under low-temperature conditions.
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