FACTORS INFLUENCING OSTEOPOROSIS IN PATIENTS WITH CORONARY HEART DISEASE AND RHEUMATOID ARTHRITIS
Keywords:
osteoporosis, coronary heart disease, rheumatoid arthritis, risk factors, cardiovascular diseases, glucocorticosteroids, bone mineral density.Abstract
Rheumatoid arthritis is a systemic disease of unclear etiology with autoimmune pathogenesis, which is characterized by chronic erosive polyarthritis. In some patients with rheumatoid arthritis, there is a discrepancy between the processes of bone resorption and bone formation, which is the cause of secondary metabolic osteopathies. Such a complication of rheumatoid arthritis with a change in the quality of bone tissue is osteoporosis. Coronary heart disease in combination with rheumatoid arthritis exacerbates risk factors leading to a decrease in bone density and an increased risk of fractures in osteoporosis, which determines the unfavorable course and significantly worsens the prognosis of the disease. Currently, a number of studies have revealed an association between an increased risk of osteoporosis (in patients with coronary heart disease in combination with rheumatoid arthritis) and the following factors: low mineral bone density, female gender, age over 65 years, early menopause, weight less than 57 kg, family history of osteoporosis, previous fractures, long-term rheumatoid arthritis and irrational glucocorticosteroid therapy. This article presents the results of an analysis of the factors leading to the development of osteoporosis in patients with coronary heart disease in combination with rheumatoid arthritis who are undergoing inpatient treatment in the rheumatology department.
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