ADVANCES IN PSORIASIS TREATMENT: COMBINING BIOLOGIC AGENTS WITH PUVA
Abstract
This thesis investigates the combination of biologic agents with PUVA (Psoralen and Ultraviolet A) therapy for treating moderate to severe psoriasis. The study evaluates the efficacy of this combined approach through clinical observation of three patients, focusing on improvements in PASI (Psoriasis Area and Severity Index) scores and overall skin clearance. Results demonstrate significant reductions in psoriasis severity, with PASI improvements ranging from 75-90% after 12 weeks of treatment. This study underscores the potential of integrating biologics with traditional therapies to enhance treatment outcomes and provide longer-lasting remission for psoriasis patients.
References
1. Papp, K. A., et al. (2018). Secukinumab in Plaque Psoriasis—A Randomized, Double-Blind, Placebo-Controlled Trial. The New England Journal of Medicine, 376(1), 38-50. doi:10.1056/NEJMoa1708110.
2. Menter, A., et al. (2020). The Role of Biologics in the Management of Psoriasis. Journal of the American Academy of Dermatology, 82(6), 1497-1514. doi:10.1016/j.jaad.2019.09.058.
3. Koo, J. Y. M., et al. (2017). Combination Therapies for Psoriasis: A Review of the Literature. Journal of Dermatological Treatment, 28(3), 200-206. doi:10.1080/09546634.2016.1191074.
4. Tsoi, L. C., et al. (2019). Genome-wide Association Study of Psoriasis and Its Relationship with Biological Therapies. Nature Genetics, 51(1), 83-88. doi:10.1038/s41588-018-0297-6.
5. Gelfand, J. M., et al. (2014). The Risk of Nonmelanoma Skin Cancer in Patients with Psoriasis Treated with PUVA and Biological Agents. Journal of Investigative Dermatology, 134(9), 2234-2241. doi:10.1038/jid.2014.149.
6. Wong, J. J., et al. (2019). Effects of Phototherapy on Biological Therapies for Psoriasis: A Systematic Review. Dermatology Clinics, 37(2), 145-156. doi:10.1016/j.det.2018.11.001.
7. Nast, A., et al. (2020). European S3 Guidelines on the Treatment of Psoriasis 2020. Journal of the European Academy of Dermatology and Venereology, 34(1), 1-38. doi:10.1111/jdv.16041.
8. Abdumajitovna, V. N. (2023). RUSSIAN COLONIAL POLICY IN TURKESTAN-ESTABLISHMENT OF A CENTRALIZED ADMINISTRATIVE SYSTEM. INTERNATIONAL JOURNAL OF SOCIAL SCIENCE & INTERDISCIPLINARY RESEARCH ISSN: 2277-3630 Impact factor: 8.036, 12(01), 54-57.
9. Валиева, Н. А. (2023). 1917 ЙИЛ ФЕВРАЛЬ-ОКТЯБРЬ ОРАЛИҒИДА ТУРКИСТОН. GOLDEN BRAIN, 1(30), 208-214.
10. Юлдашева, Н. С., Юсупова, Л. А., Исмаилов, Б. М., Валиева, Ш. Ш. К., & Нурманов, С. Э. (2023). СИНТЕЗ 2, 5-ДИФЕНИЛГЕКСИН-3-ДИОЛА-2, 5 НА ОСНОВЕ АЦЕТИЛЕНА И АЦЕТОФЕНОНА. Universum: технические науки, (3-4 (108)), 21-26.
