THE ROLE OF SELENIUM AND ZINC IN THE PATHOGENESIS AND PROGRESSION OF THYROID DISEASES
Abstract
Thyroid diseases are a significant medical problem in modern healthcare, affecting metabolism regulation and overall health. Hypothyroidism, thyrotoxicosis, and autoimmune thyroid diseases are increasingly common worldwide, posing serious health challenges [1]. Disruptions in thyroid function can lead to metabolic disorders, mental health problems, and other severe complications [2].
Several factors influence thyroid health, including deficiencies in trace elements and vitamins. Selenium, iodine, zinc, and vitamin D play crucial roles in thyroid function and may impact disease development and progression [3].
This review aims to analyze the existing literature on the effects of selenium, iodine, zinc, and vitamin D concentrations on the course and pathogenesis of thyroid diseases. By synthesizing these data, we aim to improve our understanding of the role of these trace elements and vitamins in thyroid disease etiology and treatment and to identify future research and clinical practice perspectives [4].
References
1. Zimmermann MB, Boelaert K. Iodine deficiency and thyroid disorders. Lancet Diabetes Endocrinol. 2015;3(4):286-295.
2. Kohrle J. Selenium and the thyroid. Curr Opin Endocrinol Diabetes Obes. 2015;22(5):392-401.
3. Duntas LH, Benvenga S. Selenium: an element for life. Endocrine. 2015;48(3):756-775.
4. Wertenbruch T, et al. Serum selenium levels in patients with autoimmune thyroiditis. Horm Metab Res. 2010;42(10):665-669.
5. Schomburg L. Dietary selenium and human health. Nutrients. 2016;8(2):81.
6. Derumeaux H, et al. Thyroid volume and urinary iodine in European schoolchildren. J Clin Endocrinol Metab. 2003;88(9):3851-3857.
7. Rayman MP. Selenium and human health. Lancet. 2012;379(9822):1256-1268.
8. O'Kane M, et al. Zinc and thyroid function. Biol Trace Elem Res. 2017;175(2):253-261.
9. Chmielowiec J, et al. Iodine intake and thyroid dysfunction. Thyroid. 2017;27(8):1069-1076.
10. Mirhosseini N, et al. Role of vitamin D in thyroid disease: A review. J Clin Med. 2020;9(11):3755.
11. Ventura M, Melo M, Carrilho F. Selenium and thyroid disease: from pathophysiology to treatment. Int J Endocrinol. 2017;2017:1297658.
12. Labunskyy VM, et al. Selenium metabolism and its roles in health and disease. Trends Biochem Sci. 2014;39(3):112-120.
13. Hess SY. Zinc: an essential trace element for thyroid function. Adv Nutr. 2017;8(2):177-178.
14. Mazokopakis EE, et al. The role of vitamin D in thyroid disease. Hormones. 2015;14(3):396-408.
15. Toulis KA, et al. Selenium supplementation in Hashimoto’s thyroiditis. Clin Endocrinol. 2010;72(1):75-80.
16. Prasad AS. Zinc in human health: effect of zinc on immune cells. Mol Med. 2008;14(5-6):353-357.
