DEVELOPMENT OF A 6-AMINOPURINE–LOADED THERMOSENSITIVE HYDROGEL–BASED WOUND-SEALING BIOMATERIAL
Keywords:
6-Aminopurine; Thermosensitive hydrogel; Wound-sealing biomaterial; In situ gelation; Controlled release; Tissue regeneration.Abstract
The development of advanced wound dressings capable of responding to physiological conditions represents an important direction in regenerative medicine. This study describes the design and evaluation of a thermosensitive hydrogel loaded with 6-aminopurine as a bioactive wound-sealing biomaterial. The hydrogel was formulated using temperature-responsive polymers capable of sol–gel transition at body temperature. Physicochemical characterization included gelation temperature, rheological behavior, swelling capacity, and in vitro release kinetics. Biological assessment demonstrated enhanced wound closure, reduced inflammatory response, and improved collagen organization compared to conventional dressings. The thermosensitive system allowed injectable application in liquid form followed by in situ gel formation, ensuring effective wound coverage and sustained drug release. The developed biomaterial shows strong potential for use in modern wound management strategies.
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