BIOSINTEZLANGAN AG-ZNO GIBRID TO‘LDIRUVCHISINI SAQLOVCHI YANGI NATRIY KARBOKSIMETILSELLYULOZA-PPFMA NANOKOMPOZITLARINING TERMAL VA BIOLOGIK XUSUSIYATLAR
Keywords:
karboksimetilsellyuloza, metakrilat, termal xususiyatlar, antimikrobial faollik, nanokompozitlar, yara bitish.Abstract
Ushbu tadqiqotda biomedikal qo‘llanmalar uchun mo‘ljallangan antimikrobial, antioksidant va antikancer xususiyatlarga ega yangi nanokompozit materiallar ishlab chiqildi. Avval poli(2-okso-2-(pentaftorfenoksi)etil-2-metilprop-2-enoat) (PPFMA) polimeri sintez qilinib, FTIR va NMR usullari yordamida xarakterizatsiya qilindi. So‘ngra PPFMA natriy karboksimetilsellyuloza (NaCMC) bilan in-situ gidrotermal usulda aralashtirildi. Aralashmaning moslashuvchanligi FTIR spektrlari va DSC tahlilidan olingan yagona Tg qiymati orqali tasdiqlandi. NaCMC–PPFMA aralashmasining termal va biologik xususiyatlarini yaxshilash maqsadida Prunus spinosa ekstrakti yordamida biosintez qilingan Ag–ZnO nanozarrachalari 3%, 5% va 7% og‘irlik nisbatlarida kompozitsiyaga qo‘shildi. Olingan nanokompozitlar SEM, EDX, TEM, XRD, FTIR, TGA va DSC usullari bilan o‘rganildi. Biologik sinovlar nanokompozitlarning yuqori antimikrobial faollikka ega ekanligini ko‘rsatdi. Termal tahlil natijalari Ag–ZnO qo‘shilishi natijasida materialning termal barqarorligi 22 °C ga, Tg qiymati esa 9 °C ga oshganini aniqladi. Eng yaxshi yara bitish ko‘rsatkichi NaCMC–PPFMA–3% Ag–ZnO namunasi uchun kuzatilib, 24 soatda 91.67% yara yopilishi qayd etildi. Olingan natijalar ushbu nanokompozitlarning bioxavfsiz yara qoplamalari uchun istiqbolli material ekanligini ko‘rsatadi.
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