GENETIC ASPECTS AND DIAGNOSIS OF EARLY PREGNANCY LOSS
Keywords:
vmiscarriage, genetic abnormalities, chromosomal abnormalities, aneuploidy, chromosomal microarray analysis, karyotyping, genetic diagnosis, recurrent miscarriage, genetic counseling.Abstract
Early pregnancy loss (EPL) is a prevalent reproductive complication, with genetic abnormalities being a leading cause. This article reviews the genetic factors contributing to EPL, focusing on chromosomal abnormalities, single-gene mutations, and maternal genetic predispositions. It further explores current diagnostic techniques including conventional karyotyping, chromosomal microarray analysis, and molecular genetic testing, emphasizing their role in accurate diagnosis and clinical management. Understanding these genetic aspects is essential for effective genetic counseling, risk assessment, and improving reproductive outcomes for affected couples.
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